Esther Blodgett is just another starry-eyed farm kid trying to break into the movies. Waitressing at a Hollywood party, she catches the eye of her idol Norman Maine, is sent for a screen test, and before long attains stardom as newly minted Vicki Lester. She and Norman marry, though his career soon dwindles to nothing due to his chronic alcoholism.
Nerdy Walter Paisley, a maladroit busboy at a beatnik café who doesn't fit in with the cool scene around him, attempts to woo his beautiful co-worker, Carla, by making a bust of her. When his klutziness results in the death of his landlady's cat, he panics and hides its body under a layer of plaster. But when Carla and her friends enthuse over the resulting artwork, Walter decides to create some bigger and more elaborate pieces using the same artistic process.
Art editor Madeleine Damian carries on numerous loveless affairs. After a failed relationship with advertiser Felix Courtland, the increasingly depressed Madeleine attempts suicide. When Jack Garet, her secretary and former lover, tries to blackmail her, Madeleine resigns and seeks a reclusive life. Neighbor David Cousins befriends Madeleine, but soon Courtland and Garet discover her whereabouts and disrupt her new life.
A bedridden and gravely ill man believes his wife and doctor are conspiring to kill him, and outlines his suspicions in a letter.