A small town in Texas finds itself under attack from a hungry, fifty-foot-long gila monster. No longer content to forage in the desert, the giant lizard begins chopming on motorists and train passengers before descending upon the town itself. Only Chase Winstead, a quick-thinking mechanic, can save the town from being wiped out.
With the help of her friends, Emily moves to a remote home to take better care of her brother, Zack who is diagnosed with cerebral palsy. But what they don't know is that the house is keeping a terrifying secret that will haunt them one by one.
Dr. Bill Cortner and his fiancée, Jan Compton, are driving to his lab when they get into a horrible car accident. Compton is decapitated. But Cortner is not fazed by this seemingly insurmountable hurdle. His expertise is in transplants, and he is excited to perform the first head transplant. Keeping Compton's head alive in his lab, Cortner plans the groundbreaking yet unorthodox surgery. First, however, he needs a body.
Professor Morlant, a British Egyptologist, seeks immortality through the power of a jewel buried in the tomb of an Oriental idol. Upon his death, Morlant returns to earth to seek vengeance upon those who removed the jewel from his grave.