When Letty Mason relocates to West Texas, she finds herself unsettled by the ever-present wind and sand. Arriving at her new home at the ranch of her cousin, Beverly, she receives a surprisingly cold welcome from his wife, Cora. Soon tensions in the family and unwanted attention from a trio of suitors leave Letty increasingly disturbed.
France, on the eve of the French Revolution. Henriette and Louise have been raised together as sisters. When the plague that takes their parents' lives causes Louise's blindness, they decide to travel to Paris in search of a cure, but they separate when a lustful aristocrat crosses their path.
Erstwhile childhood friends, Judah Ben-Hur and Messala meet again as adults, this time with Roman officer Messala as conqueror and Judah as a wealthy, though conquered, Israelite. A slip of a brick during a Roman parade causes Judah to be sent off as a galley slave, his property confiscated and his mother and sister imprisoned. Years later, as a result of his determination to stay alive and his willingness to aid his Roman master, Judah returns to his homeland an exalted and wealthy Roman athlete. Unable to find his mother and sister, and believing them dead, he can think of nothing else than revenge against Messala.
Two families, abolitionist Northerners the Stonemans and Southern landowners the Camerons, intertwine. When Confederate colonel Ben Cameron is captured in battle, nurse Elsie Stoneman petitions for his pardon. In Reconstruction-era South Carolina, Cameron founds the Ku Klux Klan, battling Elsie's congressman father and his African-American protégé, Silas Lynch.